Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endoplasmic reticulum export site formation and function in dendrites.

Meir Aridor1, Amy K Guzik, Anna Bielli

  • 1Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 16, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Key Considerations in Telestroke Program Management.

Continuum (Minneapolis, Minn.)·2026
Same author

Correction to: Creating Virtual Stroke Networks: Current and Future Role of Artificial Intelligence, Mobile Imaging Applications, and Telehealth in Triage and Treatment of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association.

Stroke·2026
Same author

Beyond Vesicular Traffic: The ERES as the Gateway for Biosynthetic Secretion.

Sub-cellular biochemistry·2026
Same author

Quality of life after endovascular thrombectomy: A multicenter, prospective, observational study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

Diagnostic Yield of Transthoracic Echocardiography Among US Emergency Department Observation Unit Patients Evaluated for Transient Ischemic Attack.

Critical pathways in cardiology·2026
Same author

Parvalbumin interneurons drive depth-dependent vascular responses.

iScience·2025
Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Representations of subsecond duration-based timing by complex spike synchrony in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The extended language network: Language-responsive brain areas whose contributions to language remain to be discovered.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Cortical and thalamic afferent connectomes distinguish ACC subregions of the macaque brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Neurons sort receptors in dendrites, not just the cell body. Endoplasmic reticulum export sites assemble in dendrites, influencing receptor surface expression and neuronal function.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Neurons possess elongated and polarized structures, requiring precise receptor targeting to distal plasma membranes.
  • While soma is the primary site for protein synthesis and sorting, local processes in dendrites and axons are increasingly recognized.

Purpose of the Study:

  • To investigate the location and regulation of endoplasmic reticulum (ER) export within neuronal dendrites.
  • To understand the role of ER export site assembly in dendritic protein trafficking.

Main Methods:

  • Utilized an in vitro permeabilized neuron system to control ER export site assembly.
  • Examined the sequential recruitment of Sar1 and COPII (coat protein complex II) proteins.

Main Results:

Related Experiment Videos

  • ER export sites are assembled throughout the dendritic tree via Sar1 and COPII recruitment.
  • Metabotropic glutamate receptor activation recruits the NMDA receptor subunit NR1 to these dendritic ER export sites.

Conclusions:

  • Dendritic ER export site assembly is a regulated process occurring throughout the dendritic tree.
  • Regulation of receptor assembly and ER export in dendrites is crucial for modulating receptor surface expression and neuronal function.