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Published on: February 9, 2021
Role of urinary zinc and copper on calcium oxalate stone formation
Taner Ozgurtas1, Gurer Yakut, Mahir Gulec
1Department of Biochemistry, Gulhane Medical School, Ankara, Turkey. chem352000@yahoo.com
Introduction:
It is considered that many factors may play a role in urolithiasis. Experimental and clinical studies have shown that zinc has an inhibitory effect on urolithiasis.
Materials And Methods:
In this study, urinary zinc and copper were measured in 27 healthy controls and 30 calcium oxalate stone formers.
Results:
Urinary zinc excretion was significantly higher (p < 0.001) in stone formers than healthy controls (2,575 +/- 274 and 960 +/- 80 mg/day, respectively). There was no significant difference in urinary copper excretion between healthy controls and stone formers (32.3 +/- 3.5 and 33.3 +/- 3.2 microg/day, respectively).
Conclusions:
According to our results, the potent inhibitory effect of urinary zinc excretion on urolithiasis could be reviewed.
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