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[Alkaline citrates in urology. A status report]
L Rinnab1, R E Hautmann, M Straub
1Abteilung Urologie und Kinderurologie, Arbeitsgruppe Harnsteine, Universitätsklinikum Ulm.
Der Urologe. Ausg. A
|April 16, 2004
Summary
Alkaline citrates effectively treat kidney stones and metabolic acidosis by increasing urinary pH and citrate levels. This review provides urologists with practical guidance on their use in daily practice.
Area of Science:
- Nephrology
- Urology
- Biochemistry
Context:
- Alkaline citrates are established treatments for various kidney stone types and metabolic acidosis.
- Urinary diversion procedures can lead to hyperchloremic metabolic acidosis, a condition manageable with alkaline citrates.
Purpose:
- To review current indications, therapy modalities, and metaphylactic use of alkaline citrates in urolithiasis.
- To provide practical advice for urologists based on literature and European guidelines.
Summary:
- Alkaline citrate therapy for hypocitraturic calcium nephrolithiasis, uric acid lithiasis, and cystinuria is well-documented.
- Key physiological effects include elevated urinary pH, citrate, and potassium, alongside reduced calcium excretion.
- The review incorporates recommendations from the Deutsche Gesellschaft für Urologie (DGU) and the European Association of Urology (EAU).
Impact:
- Enhances understanding of alkaline citrate's role in managing kidney stones and metabolic acidosis.
- Offers evidence-based guidance for optimizing patient treatment strategies.
- Aims to improve clinical decision-making for urologists in daily practice.