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The aqueous levels of TGF-beta2 in patients with glaucoma
Altan Atakan Ozcan1, Nusret Ozdemir, Abdullah Canataroglu
1Department of Ophthalmology, Cukurova University Faculty of Medicine, Adana, Turkey. altanoz@mail.cu.edu.tr
Purpose:
To evaluate the aqueous levels of transforming growth factor beta-2 (TGF-beta2) in open angle glaucoma patients.
Methods:
The aqueous levels of active TGF-beta2 were detected in 17 eyes of 17 patients using ELISA method. The control group consisted of 6 cataract extracted patients.
Results:
Mean age of the patients (60.8 +/- 8.8 years) was similar to that of the controls (57.5 +/- 9.8 years) (p = 0.516). Levels of TGF-beta2 in aqueous samples of glaucoma patients (2.74+/- 1.23 ng/ml) were found to be elevated when compared to those of controls (1.67 +/- 0.32 ng/ml) (p = 0.020).
Conclusion:
We might suggest that the elevated levels of TGF-beta2 in the aqueous of glaucoma patients could play a role in the pathogenesis of glaucoma.
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