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Calibration verification performance relates to proficiency testing performance.

Martin H Kroll1, Patricia E Styer, Delmiro Anthony Vasquez

  • 1Department of Clinical Chemistry, Dallas VA Medical Center, Dallas, Tex 75216, USA. martin.kroll@med.va.gov

Archives of Pathology & Laboratory Medicine
|April 17, 2004
PubMed
Summary
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Successful completion of College of American Pathologists linearity (LN) surveys correlates with improved proficiency testing (PT) performance. Laboratories participating in LN surveys showed fewer unacceptable PT results, indicating better overall accuracy.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Quality Assurance in Healthcare

Background:

  • The College of American Pathologists (CAP) has provided linearity (LN) survey materials for calibration verification since 1988.
  • LN surveys assess the ability of laboratories to verify the linear range of analytical methods.

Purpose of the Study:

  • To evaluate if successful participation in CAP LN surveys enhances proficiency testing (PT) performance.
  • To determine the impact of calibration verification on laboratory testing accuracy.

Main Methods:

  • Data from CAP LN surveys (LN1/2, LN3, LN5) and PT surveys (C, Z, K) from the year 2000 were analyzed.
  • Laboratory performance was assessed using metrics such as PT pass rates, results exceeding 2 SDs, and SD interval sums.
  • Laboratories were categorized based on LN survey participation and success.

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Main Results:

  • Laboratories enrolled in LN surveys demonstrated a lower frequency of unacceptable PT results compared to non-enrollees.
  • A significant positive association was observed between LN survey performance and PT performance for numerous analytes.
  • Successful calibration verification through LN surveys was linked to improved PT outcomes.

Conclusions:

  • Strong evidence supports a link between performance in PT surveys and LN surveys across most analytes studied.
  • Successful calibration verification, as measured by LN surveys, was associated with improved performance in 62% of the analyses.
  • These findings underscore the importance of calibration verification for maintaining high-quality laboratory testing.