Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Moderate hypoxia suppresses exercise-induced procoagulant changes.

Thomas G DeLoughery1, Deborah G Robertson, Cristina A Smith

  • 1Division of Hematology/Medical Oncology, Department of Medicine, Oregan Health and Science Univerity, Portland, OR 97239-3098, USA. delought@ohsu.edu

British Journal of Haematology
|April 17, 2004
PubMed
Summary

Hypoxia, or low oxygen, may reduce blood clot formation by decreasing exercise-induced procoagulant factors and enhancing fibrinolysis, the breakdown of blood clots.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering COVID-19 vaccine acceptance and intent in 15 developing countries: a multi-level, clustered analysis of six months of repeated, cross-sectional data.

BMC infectious diseases·2026
Same author

Iron Deficiency Anemia.

Annals of internal medicine·2026
Same author

The AABB and ICTMG issued recommendations on the restrictive use of platelet transfusions.

Annals of internal medicine·2025
Same author

Women, Iron, and Altitude-Path to the Peak.

Wilderness & environmental medicine·2025
Same author

10, 14, 19 Essentials?

Wilderness & environmental medicine·2025
Same author

Advancements in complement inhibition for PNH and primary complement-mediated thrombotic microangiopathy.

Blood advances·2025

Area of Science:

  • Physiology
  • Hematology
  • Exercise Science

Background:

  • Hypoxia is suggested to stimulate blood coagulation.
  • Exertion is known to influence hemostasis (the process of stopping bleeding).

Purpose of the Study:

  • To investigate the effects of hypoxia on coagulation and hemostasis during standardized exercise.
  • To determine if hypoxia alters exercise-induced changes in procoagulant and fibrinolytic factors.

Main Methods:

  • Subjects underwent standardized exercise protocols under both room air conditions and hypoxic conditions (12% oxygen).
  • Measurements included procoagulant factors and fibrinolytic markers, such as tissue plasminogen activator and plasminogen activator inhibitor-1.

Main Results:

Related Experiment Videos

  • Exercise at room air increased procoagulant factors and fibrinolytic markers.
  • Hypoxic exercise attenuated the increase in procoagulant factors compared to room air exercise.
  • Hypoxic exercise did not alter the increase in tissue plasminogen activator but decreased plasminogen activator inhibitor-1 expression.

Conclusions:

  • Hypoxia appears to exert an antithrombotic effect.
  • This effect may be mediated by dampening exercise-induced procoagulant activity.
  • Hypoxia also seems to stimulate the body's natural clot-dissolving mechanisms (fibrinolysis).