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Plasma aldosterone concentration in the patient with diabetes mellitus

Norman K Hollenberg1, Radomir Stevanovic, Anupam Agarwal

  • 1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. djpagecapo@rics.bwh.harvard.edu

Kidney International
|April 17, 2004
PubMed
Abstract

Insights

Patients with type 1 diabetes mellitus exhibit elevated aldosterone levels due to renin-system activation. Blocking the renin-angiotensin system (RAS) may help manage vascular injury in these patients.

Area of Science:

  • Endocrinology
  • Cardiovascular Research
  • Metabolic Diseases

Background:

  • Vascular injury is a significant complication in diabetes mellitus.
  • Renin-system activation is observed in type 1 diabetes, suggesting a role for aldosterone in vascular damage.

Purpose of the Study:

  • To investigate the renin-angiotensin-aldosterone system (RAAS) in type 1 diabetes mellitus patients.
  • To determine if RAAS activation contributes to vascular complications in diabetes.

Main Methods:

  • Studied 58 type 1 diabetes patients and 64 controls.
  • Maintained fixed sodium and potassium intake.
  • Collected samples at a consistent time to minimize circadian rhythm effects.

Main Results:

  • Type 1 diabetes patients showed increased plasma renin activity, angiotensin II, and aldosterone concentrations.
  • Angiotensin receptor blocker (candesartan) significantly impacted aldosterone levels, confirming renin-system involvement.
  • Elevated aldosterone in diabetes is linked to renin-system activation.

Conclusions:

  • Pharmacological interruption of aldosterone's effects may benefit diabetes patients.
  • Adjusting renin-angiotensin system (RAS) blocking agents is crucial for maximizing aldosterone reduction.

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