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Related Experiment Videos

Functional CCR9 expression is associated with small intestinal metastasis.

Anne Letsch1, Ulrich Keilholz, Dirk Schadendorf

  • 1Charité University Medicine Berlin, Campus Benjamin-Franklin, Hematology, Oncology and Transfusion Medicine, Berlin, Germany. anne.letsch@medizin.fu-berlin.de

The Journal of Investigative Dermatology
|April 17, 2004
PubMed
Summary

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Melanoma cells expressing the CCR9 receptor show functional responsiveness to TECK, a chemokine specific to the small intestine. This suggests aberrant CCR9 expression is linked to small intestinal metastasis.

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Metastases to the small intestine are uncommon, with melanoma being a primary site.
  • CCR9 is a chemokine receptor predominantly expressed in the small intestine and thymus.
  • TECK (thymus expressed chemokine) is the principal ligand for CCR9, selectively found in the small intestine and thymus.

Purpose of the Study:

  • To investigate the role of CCR9 and its ligand TECK in small intestinal metastases, particularly in melanoma.
  • To determine if CCR9 expression and function are associated with the site-specific tropism of melanoma metastasis.

Main Methods:

  • Assessing CCR9 expression on melanoma cell lines from various metastatic sites.
  • Evaluating the functional response of melanoma cells to TECK, including receptor downregulation and actin polymerization.

Related Experiment Videos

  • Analyzing CCR9 expression in other cancer cell lines (adenocarcinoma, colorectal, breast, lung).

    • Main Results:

    • CCR9 was highly expressed on melanoma cells and cell lines from small intestinal metastases.
    • Only melanoma cells and cell lines from small intestinal metastases responded functionally to TECK.
    • CCR9 expression was observed on an adenocarcinoma cell line (CaCo-2) with enterocytic differentiation, but not on other tested cancer cell lines.

    Conclusions:

    • Aberrant functional cell surface expression of the organ-specific chemokine receptor CCR9 is associated with metastasis to the small intestine.
    • The regulation of CCR9 receptor function appears critical in the metastatic process to the small intestine.