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[Cross reactivity among proton pump inhibitors: does it exits?]
M Garmendia Zallo1, A Sánchez Azkarate, R Kraemer Mbula
1Servicio de Alergología, Hospital de Cruces, Barakaldo, Bizkaia, Spain.
Allergologia Et Immunopathologia
|April 17, 2004
Summary
Adverse reactions to proton pump inhibitors like omeprazole can be allergic. Skin prick tests indicated a potential IgE-mediated allergy and cross-reactivity between omeprazole, pantoprazole, and lansoprazole.
Area of Science:
- Allergy and Immunology
- Pharmacology
Background:
- Limited research exists on allergic reactions to proton pump inhibitors (PPIs).
- Only two prior studies documented cross-reactivity between PPIs using skin prick tests.
Purpose of the Study:
- To investigate a suspected case of omeprazole allergy.
- To evaluate the diagnostic utility of skin prick tests for PPI allergy.
- To assess cross-reactivity among different PPIs.
Main Methods:
- A case report of a 24-year-old woman experiencing allergic symptoms after omeprazole ingestion.
- Skin prick and intradermal tests were conducted using omeprazole, pantoprazole, and lansoprazole.
Main Results:
- The patient presented with pruritus, urticaria, and angioedema.
- Skin tests were positive for all three tested proton pump inhibitors.
- Oral challenge testing was not performed due to ethical considerations.
Conclusions:
- The findings suggest a possible IgE-mediated allergic mechanism.
- Skin prick tests appear valuable for diagnosing omeprazole and related analog allergies.
- Cross-reactivity was confirmed among omeprazole, pantoprazole, and lansoprazole via skin testing.