Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early mitral deceleration and left atrial stiffness.

Paolo Marino1, Giuseppe Faggian, Paolo Bertolini

  • 1Cardiology Service, Policlinico G. B. Rossi, University of Verona, Verona 37134, Italy. paolo.marino@univr.it

American Journal of Physiology. Heart and Circulatory Physiology
|April 17, 2004
PubMed
Summary

Left atrial stiffness (KLA) is near zero during left ventricular (LV) filling deceleration time (DT). Therefore, DT accurately reflects only LV stiffness (KLV), validating its use in clinical assessments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of caveolar A1 adenosine receptor signalling blunts anti-adrenergic control in heart failure.

Cardiovascular research·2026
Same author

Downregulation of L-type Ca<sup>2+</sup> current in patients with atrial fibrillation results from altered channel gating and disruption of membrane microdomains.

Heart rhythm·2026
Same author

Interleukin 11-Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis.

Circulation research·2026
Same author

Case Report: Simultaneous presentation of end-stage heart failure with cardiogenic shock requiring emergency transplantation in monozygotic twins with myofibrillar myopathy: a previously unknown genetic disease?

Frontiers in cardiovascular medicine·2025
Same author

Molecular Network Analysis of Circulating microRNAs Highlights miR-17-5p and miR-29a-3p as Potential Biomarkers of Aortic Valve Calcification.

International journal of molecular sciences·2025
Same author

Defined Composition of Culture Media Promotes Rodent Neonatal Cardiomyocyte Maturation and Enables Functional Neuro-Cardiac Co-Culture.

Cells·2025

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Physiology

Background:

  • Left ventricular (LV) filling deceleration time (DT) is influenced by both left atrial (LA) and LV stiffness (KLA + KLV).
  • Accurate assessment of LV stiffness (KLV) using DT relies on KLA being negligible during this phase.
  • Quantifying KLA during DT is crucial for validating non-invasive KLV estimations.

Purpose of the Study:

  • To quantify left atrial stiffness (KLA) during left ventricular (LV) filling deceleration time (DT).
  • To determine if KLA significantly impacts the estimation of LV stiffness (KLV) derived from DT.

Main Methods:

  • Assessed KLV using E wave DT from transesophageal echocardiography in 15 post-cardiopulmonary bypass patients.
  • Constructed LA volume curves using mitral and pulmonary vein flow, combined with end-diastolic LA volume.

Related Experiment Videos

  • Measured simultaneous time-adjusted LA pressure to calculate KLA during the V loop and DT.

    • Main Results:

    • LA volume significantly decreased during DT (7.3 ml/m2, P < 0.001), with minimal pulmonary vein inflow.
    • Mean LA pressure remained stable (10.0 mmHg) and did not change significantly during DT.
    • Calculated KLA was close to zero during DT ([-0.002 to -0.001] mmHg/ml), despite LA volume changes.

    Conclusions:

    • Left atrial stiffness (KLA) is negligible and does not change significantly during left ventricular filling deceleration time (DT).
    • The assumption of KLA being near zero during DT is valid.
    • Doppler-derived deceleration time (DT) accurately reflects left ventricular stiffness (KLV) alone, unaffected by KLA.