Related Experiment Videos
Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress
Karen S Meir1, Eran Leitersdorf
1Department of Pathology, Hadassah University Hospital, Kiryat Hadassah, Jerusalem, Israel.
Arteriosclerosis, Thrombosis, and Vascular Biology
|April 17, 2004
Summary
The apolipoprotein E-deficient (apoE-/-) mouse model is crucial for studying atherosclerosis. This review details plaque development and highlights studies advancing our understanding of this condition.
Area of Science:
- Cardiovascular Research
- Animal Models in Disease Research
Background:
- Atherosclerosis pathogenesis is complex.
- Mouse models are essential for studying cardiovascular disease.
- The apolipoprotein E-deficient (apoE-/-) mouse spontaneously develops atherosclerotic lesions.
Purpose of the Study:
- To review the pathology and progression of atherosclerotic plaques in apoE-/- mice.
- To highlight key nutritional, pharmacological, and genetic studies using this model.
Main Methods:
- Review of existing literature, including Medline searches.
- Analysis of studies utilizing the apolipoprotein E-deficient (apoE-/-) mouse model.
- Examination of plaque development and progression in this model.
Main Results:
- The apoE-/- mouse is a widely used and reliable model for atherosclerosis research.
- Over 645 articles have utilized this model since its introduction.
- Studies have elucidated factors influencing atherogenesis through this model.
Conclusions:
- The apoE-/- mouse model significantly advances the understanding of atherosclerosis.
- Nutritional, pharmacological, and genetic interventions can be effectively studied in this model.
- This model remains a cornerstone for cardiovascular disease research.