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Related Experiment Videos

Corticosteroid binding globulin: a new target for cortisol-driven obesity.

Olga Ousova1, Véronique Guyonnet-Duperat, Nathalie Iannuccelli

  • 1Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1243-Institut National de la Santé et de la Recherche Médicale Unité 471, Université Victor Segalen Bordeaux 2, Institut François Magendie, 33077 Bordeaux, France.

Molecular Endocrinology (Baltimore, Md.)
|April 17, 2004
PubMed
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Corticosteroid-binding globulin (CBG) is identified as a key gene influencing cortisol levels and fat/muscle content in pigs. This finding links CBG to obesity susceptibility and cortisol regulation.

Area of Science:

  • Genetics
  • Animal Science
  • Endocrinology

Background:

  • Quantitative trait loci (QTL) are associated with variations in cortisol levels, fat, and muscle content in pigs.
  • Corticosteroid-binding globulin (CBG) plays a crucial role in regulating cortisol bioavailability.
  • CBG gene mapping in humans and mice suggests a conserved role in regions orthologous to pig QTL.

Purpose of the Study:

  • To investigate if the corticosteroid-binding globulin (CBG) gene is the causal gene within a pig QTL linked to cortisol levels and body composition.
  • To determine the positional and functional relevance of CBG in regulating cortisol and influencing fat and muscle content in pigs.

Main Methods:

  • Cloning of pig CBG gene and mapping its location using fluorescent in situ hybridization and radiation hybrid mapping.

Related Experiment Videos

  • Assessing genetic linkage between CBG plasma binding capacity and chromosome 7 markers flanking the cortisol-associated QTL in pig progeny.
  • Comparing CBG plasma binding capacity and mRNA expression levels between Meishan and Large White pig breeds.

    • Main Results:

    • Pig CBG gene was mapped to 7q26, precisely at the peak of the identified QTL interval.
    • Significant genetic linkage was found between CBG plasma binding capacity and chromosome 7 markers, with capacity positively correlated with fat and negatively with muscle content.
    • CBG capacity and mRNA expression were significantly higher in Meishan pigs compared to Large White pigs.

    Conclusions:

    • The corticosteroid-binding globulin (CBG) gene is strongly implicated as the causal gene for the QTL affecting cortisol levels and body composition in pigs.
    • CBG acts as a key regulator of cortisol levels and is associated with obesity susceptibility in pigs.
    • Breed-specific differences in CBG expression highlight its role in phenotypic variation.