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Hypercholesterolemia, HMG-CoA reductase inhibitors, and risk of intracerebral hemorrhage: a case-control study

Daniel Woo1, Brett M Kissela, Jane C Khoury

  • 1Department of Neurology and the Neuroscience Institute, University of Cincinnati, College of Medicine, 231 Bethesda Avenue ML 0525, Cincinnati, Ohio 45267-0525, USA. Daniel.woo@uc.edu

Stroke
|April 17, 2004
PubMed

Insights

Hypercholesterolemia, or high cholesterol, was linked to a reduced risk of intracerebral hemorrhage (ICH). Statin use did not increase ICH risk in this population-based study.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Epidemiology

Background:

  • Intracerebral hemorrhage (ICH) risk factors are crucial for prevention.
  • Previous studies suggest a link between low cholesterol and ICH.
  • The role of high cholesterol and statin use in ICH remains unclear.

Purpose of the Study:

  • To investigate the association between hypercholesterolemia and intracerebral hemorrhage (ICH).
  • To determine if HMG-CoA reductase inhibitor (statin) use is associated with ICH risk.
  • To test the hypothesis that hypercholesterolemia or statin use, or both, are independent risk factors for ICH.

Main Methods:

  • Population-based case-control study design.
  • Conditional stepwise logistic regression modeling used for analysis.
  • Inclusion of 188 ICH cases and 366 matched controls.

Main Results:

  • Hypercholesterolemia was less common in ICH cases (25%) than controls (38%).
  • Statin use was also less frequent in ICH cases (9%) compared to controls (17%).
  • Hypercholesterolemia combined with statin use showed a significantly reduced risk of ICH (OR=0.30).

Conclusions:

  • Hypercholesterolemia is associated with a lower risk of intracerebral hemorrhage.
  • Widespread statin use in the population was not found to increase ICH risk.
  • Further research is needed to clarify the relationship between statin-induced cholesterol reduction and ICH risk.
Abstract

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