Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Endogenous hyperlactatemia and insulin secretion].

G Ribes, G Valette, F Lignon

    Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A case of laryngeal rhinoscleroma.

    European annals of otorhinolaryngology, head and neck diseases·2016
    Same author

    Influence of partial volume correction in staging of head and neck squamous cell carcinoma using PET/CT.

    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2014
    Same author

    Interpretation of suspect head and neck fixations seen on PET/CT in lung cancer.

    European annals of otorhinolaryngology, head and neck diseases·2014
    Same author

    [Effects of the chelation of calcium on the vasomotor properties of histamine and adrenaline in vitro].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same author

    Influence of partial volume correction in staging of head and neck squamous cell carcinoma using PET/CT.

    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2013
    Same author

    Outpatient hemithyroidectomy.

    European annals of otorhinolaryngology, head and neck diseases·2013
    Same journal

    [Saltatory propagation of the nerve impulse in the Akiyama nerve].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Nycthemeral variations of the urinary excretion of acid mucopolysaccharides and of the blood levels of seromucoids. Influence of a hypophysial or adrenal factor].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Statistical distribution of the ABO blood groups in the population of the Bas-Rhin, and comparison with those of adjacent departments].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Method of measuring the variations in peripheral vascular capacity by the use of human serum albumin labeled with I-131].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Action of nialamide on coronary circulation. The influence exerted by a serotonin antagonist on the action of nialamide and of iproniazid].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same journal

    [Pharmacodynamics of the human round ligament. Action of acetylcholine, esterine, adrenaline and oxytocin].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    See all related articles

    Intense exercise or phenformin causes high blood lactate levels and increased insulin release in dogs. Sodium dichloroacetate treatment counteracted these effects, reducing insulin output.

    Area of Science:

    • Physiology
    • Biochemistry
    • Endocrinology

    Background:

    • Endogenous hyperlactatemia can be induced by intense muscular work or phenformin administration.
    • Hyperlactatemia is associated with changes in pancreatic and duodenal function, specifically insulin output.

    Purpose of the Study:

    • To investigate the effect of sodium dichloroacetate on phenformin-induced hyperlactatemia and subsequent insulin output in dogs.
    • To determine if sodium dichloroacetate can mitigate the metabolic consequences of hyperlactatemia.

    Main Methods:

    • Anesthetized dogs were subjected to intense muscular work or given a high dose of phenformin (20 mg/kg subcutaneously).
    • Sodium dichloroacetate (50 mg/kg/h) was perfused in a separate group of dogs prior to inducing hyperlactatemia.
    • Pancreaticoduodenal insulin output was measured in response to hyperlactatemia and the effects of sodium dichloroacetate.

    Related Experiment Videos

    Main Results:

    • Both intense muscular work and phenformin administration led to endogenous hyperlactatemia.
    • Hyperlactatemia was followed by an increased pancreaticoduodenal insulin output.
    • Previous perfusion with sodium dichloroacetate opposed the development of hyperlactatemia and reduced or suppressed the increase in insulin output.

    Conclusions:

    • Sodium dichloroacetate effectively counteracts phenformin-induced hyperlactatemia in dogs.
    • The increase in insulin output associated with hyperlactatemia can be mitigated by sodium dichloroacetate treatment.
    • These findings suggest a link between lactate levels and insulin regulation in the pancreaticoduodenal system.