Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preliminary studies on pulp capping with demineralized dentin.

W C Robson1, R W Katz

  • 1University of Michigan School of Dentistry, Ann Arbor.

Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran Toimituksia
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substrate modulation of osteoblast adhesion strength, focal adhesion kinase activation, and responsiveness to mechanical stimuli.

Molecular & cellular biomechanics : MCB·2006
Same author

Paracrine activation of extracellular signal-regulated kinase in a simple in vitro model of wounded osteoblasts.

Bone·2002
Same author

Successful treatment of adults with severe Hantavirus pulmonary syndrome with extracorporeal membrane oxygenation.

Critical care medicine·1998
Same author

The interplay of half-site sequence and spacing on the activity of direct repeat thyroid hormone response elements.

The Journal of biological chemistry·1995
Same author

DNA binding specificity and function of retinoid X receptor alpha.

The Journal of biological chemistry·1994
Same author

Specificity and mechanism of thyroid hormone induction from an octamer response element.

The Journal of biological chemistry·1994

Demineralized dentin matrix shows promise for vital pulp repair in rats. Osteoinductive factors may guide dentin bridge formation, aiding in dental healing.

Area of Science:

  • Biomaterials Science
  • Regenerative Dentistry
  • Dental Pulp Biology

Background:

  • Vital pulp therapy aims to preserve pulp vitality and function.
  • Demineralized dentin matrix (DDM) contains growth factors that can stimulate bone and dentin formation.
  • Investigating DDM's osteoinductive potential for pulp repair is crucial for regenerative dentistry.

Purpose of the Study:

  • To evaluate the efficacy of osteoinductive demineralized dentin matrix in repairing vital pulp exposures.
  • To assess the potential of DDM to guide dentin bridge formation in a rat model.

Main Methods:

  • Vital pulp exposures were created in rat molars and capped with DDM or guanidinium-extracted DDM.
  • Glass ionomer cement restorations were placed over the caps.

Related Experiment Videos

  • Histological analysis was performed after two weeks to evaluate healing and dentin bridge formation.

    • Main Results:

    • Both DDM groups showed healing when restorations were intact.
    • Preliminary evidence suggested greater reactive matrix formation in the osteoinductive DDM group.
    • Odontoblast-like cells incorporated dentin particles into the reparative dentin bridge.

    Conclusions:

    • Osteoinductive factors in demineralized dentin may promote dentin bridge formation.
    • DDM shows potential as a biomaterial for vital pulp exposure repair.
    • This rat model provides a basis for further investigation into DDM for pulp regeneration.