Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of chronic ischemia on bladder structure and function.

Kazem M Azadzoi1

  • 1Urology Research, Boston University School of Medicine, MA 02130, USA.

Advances in Experimental Medicine and Biology
|April 20, 2004
PubMed
Summary

Arterial stenosis causing bladder ischemia significantly alters bladder structure and function, with changes varying by ischemia severity. This suggests vascular issues contribute to bladder dysfunction in the elderly.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Post-Translational Modifications of Proteins in Bladder Ischemia.

Biomedicines·2024
Same author

Molecular Regulation of Concomitant Lower Urinary Tract Symptoms and Erectile Dysfunction in Pelvic Ischemia.

International journal of molecular sciences·2022
Same author

Formation of Double Stranded RNA Provokes Smooth Muscle Contractions and Structural Modifications in Bladder Ischemia.

Research and reports in urology·2022
Same author

Cellular Stress and Molecular Responses in Bladder Ischemia.

International journal of molecular sciences·2021
Same author

Mechanisms of Lower Urinary Tract Symptoms in Pelvic Ischemia.

Journal of biochemical and pharmacological research·2021
Same author

Neural regulation of sexual function in men.

World journal of clinical urology·2021

Area of Science:

  • Urology
  • Vascular Biology
  • Geriatrics

Background:

  • Arterial stenosis and insufficiency are prevalent in the elderly, often leading to significant health issues.
  • Bladder dysfunction, including detrusor instability, is a common complaint in older adults.
  • The link between vascular disease and bladder dysfunction requires further elucidation.

Purpose of the Study:

  • To investigate the impact of arterial stenosis and subsequent bladder ischemia on bladder structure and function using an animal model.
  • To differentiate the histopathophysiologic changes caused by moderate versus severe chronic bladder ischemia.
  • To explore the potential role of vascular risk factors in the development of clinical bladder dysfunction.

Main Methods:

  • Utilized an animal model to induce varying degrees of chronic arterial stenosis and bladder ischemia.
  • Assessed structural and functional changes in the bladder following ischemic events.
  • Compared histopathophysiologic alterations between moderate and severe ischemia groups.

Main Results:

  • Chronic bladder ischemia, resulting from arterial stenosis, induced marked changes in bladder structure and function.
  • Moderate and severe chronic ischemia resulted in distinct functional and structural alterations.
  • The severity of histopathophysiologic changes correlated with the degree of arterial stenosis and bladder ischemia.

Conclusions:

  • Bladder ischemia, driven by arterial stenotic disease, significantly impacts bladder physiology and morphology.
  • Findings in the animal model suggest a strong link between vascular risk factors, bladder ischemia, and clinical detrusor instability.
  • Understanding the role of vascular factors in bladder dysfunction may improve lower urinary tract symptoms (LUTS) assessment and treatment strategies.

Related Experiment Videos