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[Hydroxyethylstarch (HES)].

Joachim Boldt1

  • 1Klinik für Anästhesiologie and Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Deutschland. BoldtJ@gmx.net

Wiener Klinische Wochenschrift
|April 20, 2004
PubMed
Summary

Volume replacement therapy is crucial for critically ill patients. Modern hydroxyethylstarch (HES) preparations effectively treat hypovolemia, though specific patient groups require further research.

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Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Nephrology

Context:

  • Managing critically ill patients requires effective volume replacement therapy.
  • The optimal fluid resuscitation strategy remains a complex clinical challenge.
  • Hydroxyethylstarch (HES) solutions are widely utilized for hypovolemia due to their efficacy.

Purpose:

  • To review the role of hydroxyethylstarch (HES) in volume replacement therapy for critically ill patients.
  • To discuss the physico-chemical properties and clinical considerations of HES preparations.
  • To identify remaining questions regarding HES use in specific populations.

Summary:

  • Adequate volume replacement is essential for hemodynamics, organ perfusion, and microcirculation in critical illness.
  • Modern HES preparations demonstrate efficacy in treating hypovolemia with minimal adverse effects.
  • Considerations for HES use persist in pediatric, pregnant, renal impairment, and burn patient populations.

Impact:

  • Provides a comprehensive overview of HES in critical care fluid management.
  • Highlights the safety and efficacy of contemporary HES formulations.
  • Identifies knowledge gaps for future research in specialized patient groups.

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