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Related Experiment Videos

Crystal forms of ketorolac.

Young-Taek Sohn1, Hyun Ok Seo

  • 1College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea. ytsohn@duksung.ac.kr

Archives of Pharmacal Research
|April 20, 2004
PubMed
Summary

This study identified four crystal forms of ketorolac, revealing significant differences in solubility and stability. Ketorolac

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Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry

Background:

  • Ketorolac is a non-steroidal anti-inflammatory drug (NSAID).
  • Understanding its crystalline forms (polymorphs) is crucial for drug formulation and efficacy.

Purpose of the Study:

  • To investigate the polymorphism of ketorolac.
  • To characterize different ketorolac crystal forms and assess their physical stability and solubility.

Main Methods:

  • Recrystallization in organic solvents under varied conditions.
  • Characterization using X-ray powder diffraction (XRD), Differential Scanning Calorimetry (DSC), and Thermogravimetric Analysis (TGA).
  • Dissolution studies in water at 37°C.

Main Results:

  • Four distinct crystal forms of ketorolac were obtained.
  • Significant differences in solubility were observed, with Form I exhibiting the highest solubility (Form I > Form II > Form III > Form IV).
  • Forms I and III demonstrated good physical stability over 60 days, while Forms II and IV interconverted to Forms III and I, respectively.

Conclusions:

  • Ketorolac exhibits readily inter-convertible crystalline polymorphism.
  • The observed polymorphism and stability profiles necessitate consideration during drug formulation to ensure consistent therapeutic outcomes.

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