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Related Experiment Videos

Depersonalisation disorder: a contemporary overview.

Daphne Simeon1

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.

CNS Drugs
|April 20, 2004
PubMed
Summary
This summary is machine-generated.

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Depersonalisation disorder involves persistent feelings of detachment from oneself and reality. Current treatments lack established efficacy, highlighting the need for novel therapeutic approaches for this challenging condition.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Dissociative Disorders

Background:

  • Depersonalisation disorder is characterized by persistent depersonalisation and derealisation.
  • It affects individuals around 16 years old with a long-term, continuous course.
  • Comorbid mood, anxiety, and personality disorders are common, but childhood trauma is a significant associated factor.

Purpose of the Study:

  • To review the current understanding of depersonalisation disorder, including its characteristics, precipitants, neurobiological underpinnings, and treatment landscape.
  • To identify gaps in knowledge and highlight the urgent need for effective therapeutic interventions.

Main Methods:

  • Literature review of studies on depersonalisation disorder, encompassing clinical characteristics, neurochemical and neuroimaging findings, and treatment outcomes.

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  • Analysis of existing pharmacotherapy and psychotherapy approaches.

    • Main Results:

    • Depersonalisation disorder is associated with severe stress, substance use, and childhood interpersonal trauma.
    • Neurochemical pathways (serotonergic, opioid, glutamatergic) and brain alterations (sensory cortex, prefrontal cortex, limbic system) are implicated.
    • Current treatments, including pharmacotherapy (e.g., clomipramine, fluoxetine) and psychotherapy, lack established efficacy.

    Conclusions:

    • Depersonalisation disorder presents significant challenges due to its refractory nature and lack of effective treatments.
    • Further research into novel therapeutic strategies is crucial for improving outcomes for affected individuals.