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Drug metabolism and ageing

M T Kinirons1, M S O'Mahony

  • 1Department of Health Care of the Elderly, Guy's, King's, and St Thomas' School of Medicine, King's College London, London, UK. mark.kinirons@gstt.sthames.nhs.uk

British Journal of Clinical Pharmacology
|April 20, 2004
PubMed
Summary

Drug metabolism significantly changes with aging, affecting cytochrome P450 enzymes and transporters. Frail older individuals exhibit altered drug disposition compared to healthy elderly or young adults.

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