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Updated: Aug 24, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
11:49

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

Novel G-protein coupled receptor ligands and neurohypophysial hormones

Y Ueta1, Y Ozaki, J Saito

  • 1Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. yoichi@med.uoeh-u.ac.jp

Journal of Neuroendocrinology
|April 20, 2004
PubMed

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G-protein Coupled Receptors

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G Protein-coupled Receptors

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Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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Two...
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Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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