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International trends in prostate-cancer mortality: the decrease is continuing and spreading.

P D Baade1, M D Coory, J F Aitken

  • 1Cancer Epidemiology Unit, Queensland Cancer Fund, PO Box 201, Spring Hill QLD 4004, Australia. peterb@qcfepi.org.au

Cancer Causes & Control : CCC
|April 20, 2004
PubMed
Summary
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Prostate cancer mortality is declining in 12 developed nations. These reductions in prostate cancer deaths may be linked to increased PSA screening and improved early-stage disease treatment.

Area of Science:

  • Oncology
  • Public Health
  • Epidemiology

Background:

  • Prostate cancer remains a significant global health concern.
  • Monitoring mortality trends is crucial for assessing public health interventions.

Purpose of the Study:

  • To evaluate recent trends in prostate cancer mortality rates.
  • To analyze changes across 24 developed countries.

Main Methods:

  • Utilized World Health Organization mortality data for men aged 50-79.
  • Employed joinpoint regression models to assess age-standardized mortality rate trends.

Main Results:

  • Significant prostate cancer mortality reductions observed in the UK, US, Austria, Canada, Italy, France, Germany, Australia, and Spain.

Related Experiment Videos

  • Observable downward trends also noted in the Netherlands, Ireland, and Sweden.
  • Overall, 12 out of 24 developed countries showed declining prostate cancer mortality.

    • Conclusions:

    • Prostate cancer mortality declines are evident in half of the analyzed developed countries.
    • Increased PSA screening and enhanced treatment of early-stage disease are plausible contributing factors.
    • Further research is warranted to confirm the impact of screening and treatment on mortality trends.