Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Imaging the ischaemic penumbra.

Joseph V Guadagno1, Geoffrey A Donnan, Romesh Markus

  • 1Departments of Neurology and Radiology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

Current Opinion in Neurology
|April 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From the ASPREE investigators: Response to Wittes et al.

Clinical trials (London, England)·2025
Same author

Robotic Stroke Thrombectomy: A Feasibility and Efficacy Study in Flow Models.

Journal of stroke·2025
Same author

Persistent Tissue-Level Hypoperfusion (No-Reflow) Negates the Clinical Benefit of Successful Thrombectomy.

Stroke·2025
Same author

Submaximal Angioplasty for Severe Intracranial Atherosclerotic Stenosis: Benefit of Revascularization at Last.

Stroke·2025
Same author

Costs and Benefits of the Melbourne Mobile Stroke Unit Compared With Standard Ambulance: Causal Analysis Using Observational Linked Data.

Stroke·2025
Same author

Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data.

International journal of stroke : official journal of the International Stroke Society·2025

Advanced imaging techniques are crucial for understanding acute stroke and identifying treatment opportunities. Novel methods for imaging the penumbra continue to improve our grasp of ischemic processes.

Area of Science:

  • Neuroscience
  • Radiology
  • Medical Imaging

Background:

  • Imaging the penumbra is vital for identifying stroke patients eligible for thrombolysis.
  • Understanding the ischemic process can reveal new therapeutic intervention targets.

Purpose of the Study:

  • To review recent imaging studies of the acute stroke process.
  • To explore advancements in imaging the penumbra for therapeutic development.

Main Methods:

  • Review of recent imaging studies focusing on acute stroke.
  • Analysis of perfusion-computed tomography, computed tomography angiography, diffusion-weighted imaging, perfusion-weighted imaging, and positron emission tomography.

Main Results:

  • Diffusion-perfusion mismatch is an oversimplification; time-to-peak may not reflect true penumbral perfusion.

Related Experiment Videos

  • Diffusion-weighted imaging lesions can be reversible due to early reperfusion, potentially indicating selective neuronal damage.
  • Late secondary injury, marked by reappearing diffusion-weighted imaging lesions, is a new finding with unknown mechanisms.
  • Diffusion-weighted imaging-perfusion-weighted imaging is the most useful clinical approach for mapping stroke pathophysiology.
  • Positron emission tomography with flumazenil and fluoromisonidazole aids in understanding neuronal integrity, infarction thresholds, and brain hypoxia.

    • Conclusions:

    • Novel imaging of the penumbra advances the understanding of acute ischemic stroke.
    • Continued research in penumbra imaging is key to developing effective therapeutic strategies.