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Vacuum-assisted closure use in calciphylaxis.

Osa Emohare1, Areta Kowal-Vern, Dorion Wiley

  • 1Imperial College, Faculty of Medicine, London, United Kingdom.

The Journal of Burn Care & Rehabilitation
|April 20, 2004
PubMed
Summary
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Vacuum-assisted closure (VAC) shows potential for healing calciphylaxis-induced chronic wounds. However, its effectiveness may be limited in cases of extensive necrosis and fungal infections.

Area of Science:

  • Dermatology
  • Nephrology
  • Wound Care

Background:

  • Calciphylaxis presents a significant challenge in wound healing, often leading to chronic, non-healing wounds.
  • This study evaluates the efficacy of vacuum-assisted closure (VAC) in managing calciphylaxis-related wounds.

Observation:

  • Two patients with type 2 diabetes and calciphylaxis were treated; one experienced progressive skin necrosis from 18% to 48% TBSA, while the other progressed from 5% to 10% TBSA.
  • The patient with less extensive wounds showed positive healing outcomes with VAC therapy.

Findings:

  • Vacuum-assisted closure (VAC) demonstrated value in healing calciphylaxis wounds, particularly in less severe cases.
  • Extensive contiguous wounds and compromised skin integrity posed challenges, with one patient developing a fatal fungal infection.

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Implications:

  • VAC therapy may be a beneficial adjunct in managing calciphylaxis wounds, but careful patient selection is crucial.
  • Further research is needed to optimize VAC application for extensive calciphylaxis wounds and mitigate risks like secondary infections.