Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin E reduces cisplatin ototoxicity.

James G Kalkanis1, Craig Whitworth, Leonard P Rybak

  • 1Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794-19653, USA.

The Laryngoscope
|April 20, 2004
PubMed
Summary

Vitamin E protects against cisplatin-induced hearing loss in rats. This study shows vitamin E (alpha-tocopherol) significantly reduces ototoxicity caused by cisplatin, a common chemotherapy drug.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cochlear amyloid beta 42-mediated hearing loss: A marker of preclinical Alzheimer's disease.

Neural regeneration research·2026
Same author

Cochlear Amyloid-β42 Accumulation Drives Progressive Auditory Neuropathy in 5XFAD Mice: A Potential Biomarker for Early Alzheimer's Disease.

Research square·2025
Same author

Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation.

Frontiers in immunology·2025
Same author

Effects of natural products on cisplatin ototoxicity and chemotherapeutic efficacy.

Expert opinion on drug metabolism & toxicology·2023
Same author

Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity.

Frontiers in immunology·2023
Same author

Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity.

Antioxidants (Basel, Switzerland)·2021

Area of Science:

  • Ototoxicity research
  • Chemotherapy side effect management
  • Free radical scavenging mechanisms

Background:

  • Cisplatin is a vital chemotherapy agent but causes significant ototoxicity, limiting its use.
  • Vitamin E, an antioxidant, has shown protective effects against cisplatin-induced damage in other organs.
  • The potential of vitamin E as an otoprotective agent against cisplatin remains to be fully elucidated.

Purpose of the Study:

  • To investigate the efficacy of vitamin E in preventing cisplatin-induced ototoxicity.
  • To evaluate the protective role of vitamin E using a rat model.
  • To determine if vitamin E can mitigate hearing threshold shifts caused by cisplatin.

Main Methods:

  • A prospective, randomized controlled trial was conducted on Wistar rats.

Related Experiment Videos

  • Rats were administered cisplatin with or without vitamin E (alpha-tocopherol) pretreatment.
  • Auditory brainstem response (ABR) testing and scanning electron microscopy were used to assess hearing function and cochlear damage.

    • Main Results:

    • Cisplatin administration led to significant hearing loss, particularly at higher frequencies, evidenced by auditory threshold shifts.
    • Rats pretreated with vitamin E exhibited significantly less hearing loss compared to the control group receiving cisplatin alone.
    • Scanning electron microscopy confirmed greater preservation of outer hair cells in the cochleae of vitamin E-treated rats.

    Conclusions:

    • Vitamin E demonstrates a protective effect against cisplatin-induced ototoxicity in a rat model.
    • Pretreatment with vitamin E may be a viable strategy to mitigate hearing damage associated with cisplatin chemotherapy.
    • Further research is warranted to explore clinical applications of vitamin E for otoprotection during cisplatin therapy.