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Updated: Aug 8, 2026

Gramicidin-based Fluorescence Assay; for Determining Small Molecules Potential for Modifying Lipid Bilayer Properties
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Drug-phospholipid interactions: role in aminoglycoside nephrotoxicity

G J Kaloyanides1

  • 1Department of Medicine, School of Medicine State University of New York, Stony Brook 11794-8152.

Renal Failure
|January 1, 1992
PubMed
Summary

Aminoglycoside antibiotics cause kidney damage by accumulating in lysosomes and disrupting cell membranes. Polyaspartic acid protects against this nephrotoxicity by forming complexes with the drugs, preventing cellular injury.

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