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Safety evaluation of natural flavour complexes.
R L Smith1, T B Adams, S M Cohen
1Division of Biomedical Sciences, Section of Molecular Toxicology, Imperial College School of Medicine, South Kensington, London, UK.
Toxicology Letters
|April 20, 2004
Summary
A new 12-step safety evaluation procedure, "the naturals paradigm," assesses Natural Flavour Complexes (NFCs). This systematic approach ensures the safety of complex flavor mixtures derived from botanical sources.
Area of Science:
- Food Science and Technology
- Toxicology
- Chemical Safety Assessment
Background:
- Natural Flavour Complexes (NFCs) are complex mixtures derived from botanical sources, often foods.
- Evaluating the safety of these complex mixtures requires a structured approach.
Purpose of the Study:
- To present and discuss a novel 12-step procedure, 'the naturals paradigm,' for the safety evaluation of NFCs.
- To outline a systematic methodology for assessing the safety of complex flavor ingredients.
Main Methods:
- Characterization of NFC chemical composition and review of historical dietary use data.
- Classification of constituents into 33 congeneric groups and 3 toxic potential classes.
- Determination of per capita intake, metabolic pathways, and toxicological data requirements for each group.
Main Results:
- The procedure systematically evaluates NFCs by considering constituent properties, exposure, and toxicological data.
- Initial experiences with 'the naturals paradigm' show promising results for comprehensive safety assessment.
Conclusions:
- The 12-step 'naturals paradigm' provides a robust framework for NFC safety evaluation.
- Further application and potential modification of the system will confirm its long-term utility in ensuring food ingredient safety.