Wavefront-optimized ablation profiles: theoretical background

To describe a method for calculating wavefront-optimized ablation profiles to precompensate for the spherical aberration and higher-order astigmatism induced by myopic, hyperopic, and astigmatic corneal laser corrections.

IROC-Institut für Refraktive und Ophthalmo-Chirurgie, and Institute for Biomedical Engineering, Swiss Federal Institute of Technology, Zürich, Switzerland.

The basic ablation profile for myopic, hyperopic, and astigmatic correction is derived from the 2nd-order Zernike representation of wavefront aberrations. Including 4th-order spherical aberration and higher-order astigmatism in the theoretical calculation of the ablation profile allows precompensation for the expected amount of higher-order aberrations (HOAs). The shapes of wavefront-optimized ablation profiles are compared with the shapes of "classic" ablation profiles for myopic and astigmatic corrections.

The introduction of precompensating spherical aberration and higher-order astigmatism leads to a more aspheric ablation profile with a significant increase in ablation depth (up to 35%) in the midperiphery of the optical zone. The central ablation depth remains unchanged in the myopic correction but increases by 3% in cylinder correction.

Wavefront-optimized ablation profiles provide a simple method to precompensate for the expected 4th-order spherical aberration and higher-order astigmatism in the average eye. Further clinical studies must be performed to prove the theoretical results; demonstrate the reduction in HOAs; and predict safety, predictability, and stability of wavefront-optimized ablation profiles.