Structure, function and evolution of multidomain proteins
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Updated: Aug 24, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
Published on: January 26, 2024
Christine Vogel1, Matthew Bashton, Nicola D Kerrison
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. cvogel@mrc-lmb.cam.ac.uk
Abstract:
Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.
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