Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombospondin levels in patients with malignancy.

G P Tuszynski1, M Smith, V L Rothman

  • 1Department of Medicine, Medical College of Pennsylvania, Philadelphia 19129.

Thrombosis and Haemostasis
|June 1, 1992
PubMed
Summary

Elevated thrombospondin (TSP) blood levels are common in patients with gastrointestinal, breast, and lung cancers. This suggests TSP may play a role in cancer metastasis and could be a potential blood marker for detecting metastasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The immunomodulatory role of angiocidin, a novel angiogenesis inhibitor.

Current pharmaceutical design·2009
Same author

Endothelial apoptotic activity of angiocidin is dependent on its polyubiquitin binding activity.

British journal of cancer·2005
Same author

Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.

The Journal of surgical research·2004
Same author

Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.

Pathology oncology research : POR·2002
Same author

Age-related effects on atherogenesis and scavenger enzymes of intracranial and extracranial arteries in men without classic risk factors for atherosclerosis.

Stroke·2001
Same author

The role of thrombospondin-1 in tumor progression.

Experimental biology and medicine (Maywood, N.J.)·2001

Area of Science:

  • Biochemistry
  • Oncology
  • Immunology

Background:

  • Thrombospondin (TSP) is a glycoprotein found in platelets and tissues.
  • TSP promotes cell adhesion, platelet aggregation, and has been linked to tumor metastasis in murine models.
  • Thromboembolic events are frequent in patients with metastatic cancer.

Purpose of the Study:

  • To investigate the role of TSP in human cancer by measuring TSP blood levels in patients with various malignancies.
  • To determine if TSP blood levels can serve as a marker for cancer metastasis.

Main Methods:

  • Blood TSP levels were measured using indirect enzyme-linked immunosorbent assay (ELISA).
  • TSP levels were compared between 20 control subjects (healthy and acutely ill) and patients with gastrointestinal, breast, and lung cancer.

Related Experiment Videos

  • Platelet counts were assessed to rule out their influence on TSP levels.

    • Main Results:

    • Patients with GI, breast, and lung cancer showed significantly elevated TSP blood levels compared to controls.
    • 91% of GI cancer patients, 72% of breast cancer patients, and 88% of lung cancer patients had TSP levels above the control mean.
    • Elevated TSP levels were not attributed to increased platelet counts.

    Conclusions:

    • TSP may play a role in tumor cell metastasis in humans.
    • Blood TSP levels could potentially serve as a diagnostic marker for cancer metastasis.