Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatorenal syndrome.

Andrés Cárdenas1, Vicente Arroyo

  • 1Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Annals of Hepatology
|April 20, 2004
PubMed
Summary

Hepatorenal syndrome, a severe kidney complication in advanced cirrhosis, involves renal vasoconstriction and circulatory underfilling. Pharmacological therapies offer a promising bridge to liver transplantation for patients with this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and childhood vaccine-induced immunity.

Environmental health : a global access science source·2026
Same author

DNA methylation clocks and cognitive status among older adults in the US, NHANES 1999-2002.

Epigenetics reports·2026
Same author

Long-term molecular embedding of early life adversity: leukocyte DNA methylation and gene expression associations from childhood to young adulthood.

Epigenomics·2026
Same author

Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence.

Environmental science & technology·2026
Same author

Identification of DNA methylation signatures of smoking in women and associations with cardiovascular disease mortality.

Communications biology·2026
Same author

Health insurance, healthcare access, and their roles in the association between blood lead levels and epigenetic aging in United States adults.

GeroScience·2026

Area of Science:

  • Hepatology
  • Nephrology
  • Gastroenterology

Background:

  • Hepatorenal syndrome (HRS) is a critical complication of advanced cirrhosis.
  • It is characterized by renal failure, altered systemic blood pressure, and activated endogenous vasoactive systems.
  • Pathogenesis involves splanchnic arterial vasodilation leading to arterial underfilling and compensatory vasoconstriction.

Purpose of the Study:

  • To summarize the understanding of hepatorenal syndrome.
  • To outline diagnostic criteria and prognostic outlook.
  • To review current and emerging therapeutic strategies.

Main Methods:

  • Review of established diagnostic criteria for hepatorenal syndrome.
  • Analysis of the underlying pathophysiology of renal failure in cirrhosis.
  • Evaluation of pharmacological interventions and preventive measures.

Main Results:

  • Renal failure in HRS stems from severe renal vasoconstriction in late-stage cirrhosis.
  • Diagnosis relies on excluding other causes of renal failure.
  • Prognosis is poor; liver transplantation is optimal but often limited.
  • Vasoconstrictor drugs (terlipressin, midodrine, octreotide, norepinephrine) show promise as a bridge to transplantation.
  • Albumin infusion and pentoxifylline are recommended for prevention in specific patient groups.

Conclusions:

  • Hepatorenal syndrome presents a significant clinical challenge in advanced cirrhosis.
  • Effective management strategies are crucial for improving patient outcomes.
  • Pharmacological therapies and preventive measures play a vital role in patient care and bridging to transplantation.

Related Experiment Videos