Biological evaluation of analogues of an insect neuropeptide proctolin
Iwona Woźnica1, Wioletta Szeszel-Fedorowicz, Grzegorz Rosińskiand
1Faculty of Chemistry, University of Wrocław, Wrocław, Poland.
Acta Biochimica Polonica
|April 20, 2004
Abstract:
Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.
