Related Experiment Video
Updated: Aug 24, 2026

Mass Spectrometric Analysis of Glycosphingolipid Antigens
Published on: April 16, 2013
Morphological and immunological characterization of immunostimulatory complexes based on glycoglycerolipids from
Irina A Lee1, Alexander M Popov, Nina M Sanina
1Pacific Institute of Bioorganic Chemistry FEBRAS, Vladivostok, Russia. irinali@piboc.dvo.ru
Abstract:
Some physicochemical properties of glycoglycerolipids (monogalactosyldiacylglycerol, digalactosyldiacylglycerol and sulfoquinovosyldiacylglycerol) from the sea algae Laminaria japonica, as well as their ability to become incorporate into immunostimulating complexes (ISCOMs), used as a delivery system of microbial and tumor antigens in vesicular form, were studied. These glycolipids were found to differ essentially in fatty acid composition, unsaturation index and thermotropic behavior. The possibility of ISCOM modification by embedding the glycolipids studied instead of a phospholipid component in vesicles was shown. A preliminary research of the immunogenicity of the pore-forming protein from Yersinia pseudotuberculosis in modified (by monogalactosyldiacylglycerol) and typical (egg phosphatidylcholine) ISCOMs did not reveal a significant enhancement of immune response in comparison with that of isolated protein.
Related Concept Videos
Proteoglycans
Glycocalyx and its Functions
Components of...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
