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Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel
1Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Summary
New hematologic analyzers provide plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW). This study found a significant correlation between PDW and red blood cell distribution width (RDW), suggesting co-occurring anisocytosis.
Area of Science:
- Hematology
- Clinical Pathology
Background:
- Peripheral blood platelet quantitation is a standard diagnostic tool.
- Hematologic analyzers now offer advanced erythrocyte and platelet indices.
- Key platelet parameters include plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW).
Purpose of the Study:
- To determine the expected values for PCT, MPV, and PDW.
- To investigate the correlation between these platelet parameters and corresponding red blood cell indices (HCT, MCV, RDW).
Main Methods:
- Analysis of blood samples from 215 volunteers.
- Utilized the Technicon H*3 hematologic analyzer for platelet parameter assessment.
- Statistical analysis to evaluate correlations between platelet and red blood cell parameters.
Main Results:
- Established average values and ranges for PCT (0.24 +/- 0.05%), MPV (12.79 +/- 5.91 fL), and PDW (46.79 +/- 2.70%).
- No significant correlation was found between PCT and hematocrit (HCT), nor between MPV and mean corpuscular volume (MCV).
- A significant positive correlation was observed between platelet distribution width (PDW) and red blood cell distribution width (RDW).
Conclusions:
- The significant correlation between PDW and RDW suggests that anisocytosis (variation in cell size) in red blood cells and platelets may occur concurrently.
- These findings represent initial observations, highlighting the need for further comprehensive research into platelet parameter evaluation.