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Published on: December 10, 2013

Adenovirus infection in hospitalized immunocompetent children

Nir Peled1, Charles Nakar, Henri Huberman

  • 1Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.

Clinical Pediatrics
|April 20, 2004
PubMed

Insights

Adenovirus infections in healthy children can cause significant illness, leading to hospitalization. High serum lactic dehydrogenase (LDH) and low oxygen saturation at admission predict longer hospital stays for pediatric adenovirus patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Clinical Medicine

Background:

  • Adenovirus infections are common in children.
  • While often mild, severe cases requiring hospitalization can occur in immunocompetent children.
  • Understanding clinical features is crucial for managing pediatric adenovirus cases.

Purpose of the Study:

  • To investigate the clinical characteristics of immunocompetent children hospitalized with adenovirus infection.
  • To identify predictors of disease severity and hospitalization duration.
  • To highlight the potential morbidity of adenovirus in healthy children.

Main Methods:

  • Retrospective review of 78 immunocompetent children hospitalized with community-acquired adenovirus infection over two years.
  • Analysis of clinical data including symptoms, fever duration, and laboratory values.
  • Correlation analysis to identify factors predicting hospitalization duration.

Main Results:

  • Children presented with fever after a median of 5.7 days of illness.
  • Hospitalization duration correlated with lethargy, lung crackles, hypoxia, impaired liver tests, and elevated serum lactic dehydrogenase (LDH).
  • Serum LDH levels and hypoxemia predicted 70% of the variance in hospital stay.

Conclusions:

  • Adenovirus infection can cause significant morbidity in immunocompetent children.
  • Elevated serum LDH and hypoxemia are key indicators of prolonged hospitalization.
  • Early identification of these markers can aid in managing pediatric adenovirus cases.

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