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Updated: Aug 15, 2026

Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
Published on: March 18, 2012
All in the family: aldose reductase and closely related aldo-keto reductases
1Department of Ophthalmology and Visual Sciences, Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. petrash@wustl.edu
Abstract:
Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications. In addition to polyol synthesis, aldose reductase may have multiple other activities that intersect with signal processing and oxidative defense mechanisms. Multiple aldose reductase-like proteins have been discovered to have structures and catalytic properties that broadly overlap those of aldose reductase. This chapter will summarize new insights into properties and functions of aldose reductase and closely related members of the aldo-keto reductase enzyme superfamily.
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