Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MAGUKs in synapse assembly and function: an emerging view.

J M Montgomery1, P L Zamorano, C C Garner

  • 1Departmentof Psychiatry and Behavior Sciences, Nancy Friend Pritzker Laboratory, Stanford University, 1200 Welch Rd., Palo Alto, California 94304-5485, USA.

Cellular and Molecular Life Sciences : CMLS
|April 20, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions.

Frontiers in cellular and infection microbiology·2023
Same author

Advanced Spectral Analysis Program.

The Review of scientific instruments·2019
Same author

A simple and portable multi-channel pyrometer allowing temperature measurements down to 800 K on the microsecond scale.

The Review of scientific instruments·2019
Same author

Reduced sensory stimulation alters the molecular make-up of glutamatergic hair cell synapses in the developing cochlea.

Neuroscience·2016
Same author

Serologic evidence for hepatitis E virus infection among patients with undifferentiated acute febrile illness in Kibera, Kenya.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2016
Same author

Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains.

Journal of neurodegenerative diseases·2015
Same journal

Ablation of the renal tubular gluconeogenic enzyme PCK1 drives AKI-to-CKD transition by negatively regulating the TGF-β/Smad3 signaling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

LncRNA modulates Dpp-mediated wing development to influence flight in Aedes aegypti.

Cellular and molecular life sciences : CMLS·2026
Same journal

TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.

Cellular and molecular life sciences : CMLS·2026
Same journal

PRMT5-Cacna1d axis maintains calcium homeostasis to regulate postnatal motor development in mice.

Cellular and molecular life sciences : CMLS·2026
Same journal

Advances and clinical potential of epigenome editing.

Cellular and molecular life sciences : CMLS·2026
Same journal

Correction to: SIRT3 activation protects from nabumetone-induced mitochondrial toxicity in adult human cardiomyocytes.

Cellular and molecular life sciences : CMLS·2026
See all related articles

Membrane-associated guanylate kinase homologs (MAGUKs) are key organizers in brain development. This review details MAGUKs roles in forming, maintaining, and adapting the vertebrate central nervous system

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Neuronal morphogenesis, synaptogenesis, and synaptic plasticity are crucial for nervous system development.
  • Understanding neural circuitry relies on identifying key molecular players.
  • Membrane-associated guanylate kinase homologs (MAGUKs) are central organizers of protein signaling complexes at synapses.

Purpose of the Study:

  • To review the critical roles of MAGUK protein subfamilies.
  • To elucidate MAGUK involvement in the formation, maintenance, and plasticity of glutamatergic synapses in the vertebrate central nervous system.

Main Methods:

  • This review synthesizes existing literature on MAGUKs.
  • Focuses on molecular mechanisms and their impact on synaptic structure and function.

Related Experiment Videos

Main Results:

  • MAGUKs are essential for the transport, anchoring, and signaling of synaptic receptors and ion channels.
  • Specific MAGUK subfamilies orchestrate key events in glutamatergic synapse development and function.

Conclusions:

  • MAGUKs are indispensable for establishing and refining neural connections.
  • Further research into MAGUKs will illuminate mechanisms of nervous system development and disorders.