Targeting the immune system: novel therapeutic approaches in squamous cell carcinoma of the head and neck

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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

Thomas K Hoffmann1, Henning Bier, Theresa L Whiteside

  • 1Department of Otorhinolaryngology, Heinrich-Heine-University, Moorenstr. 5, 40225 Düsseldorf, Germany. tkhoffmann@uni-duesseldorf.de

Cancer Immunology, Immunotherapy : CII
|April 20, 2004
PubMed

Insights

Novel immunotherapies are crucial for head and neck squamous cell carcinoma (HNSCC) due to poor survival rates. These biologic therapies aim to boost antitumor immunity and overcome immune suppression for better patient outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Head and Neck Cancer Research

Background:

  • Squamous cell carcinoma of the head and neck (SCCHN) remains a significant challenge with stagnant survival rates despite conventional treatments.
  • SCCHN is characterized by a highly immunosuppressive tumor microenvironment, hindering effective host immune responses.
  • Patients with SCCHN often present with compromised immune systems, necessitating strategies to restore immune function.

Purpose of the Study:

  • To review recent advancements in immunotherapy for SCCHN.
  • To explore novel biologic therapies that can induce or enhance antitumor immune responses.
  • To discuss the potential of immunotherapy as a complementary approach to conventional treatments for SCCHN.

Main Methods:

  • Review of current literature on SCCHN immunotherapy.
  • Summary of techniques including nonspecific immune stimulation, monoclonal antibodies, adoptive immunotherapy, genetic engineering, and anticancer vaccines.
  • Analysis of strategies to restore immune function and alter malignant cell attributes.

Main Results:

  • Immunotherapy offers promising complementary strategies for SCCHN treatment.
  • Various approaches like immune stimulation, targeted antibodies, cell-based therapies, and vaccines are being investigated.
  • Restoring host immune functions and modifying tumor cells are key to effective antitumor responses.

Conclusions:

  • Biologic therapies hold significant potential as future treatment options for SCCHN.
  • Combination of immunotherapy with conventional treatments may improve patient outcomes.
  • Further research into immunotherapy is essential for developing more effective HNSCC treatments.

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