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Effect of cadmium and/or selenium on liver mitochondria and rough endoplasmic reticulum in the rat
J L Early1, V K Nonavinakere, A Weaver
1Florida Agricultural & Mechanical University, College of Pharmacy and Pharmaceutical Sciences, Tallahasee 32307.
Toxicology Letters
|August 1, 1992
Abstract:
This study was conducted to investigate the effect of cadmium (Cd) and/or selenium (Se) on hepatic mitochondria and rough endoplasmic reticulum (RER). Male Sprague Dawley derived rats (150-200 g) received sodium acetate (NaAc; 1.23 mg/kg), Cd (0.84 mg/kg), and/or Se (1.6 mg/kg) intraperitoneally. Livers were perfused with 2% glutaraldehyde at 48 h, 72 h, or 96 h after treatment and prepared for electronmicroscopy. Results indicate that Cd and/or Se are capable of inflicting mitochondrial and RER structural changes, and the damage by Cd alone is more severe than Se alone or with Cd.