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Updated: Aug 24, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Deoxypodophyllotoxin reduces skin pigmentation of brown Guinea pigs
Hyunjung Choi1, Jeongho Lee, Hyun-Jung Shin
1Skin Research Institute, R and D Center, Amore-Pacific Corp., Kyounggi-do, Korea.
Abstract:
In this report, we have demonstrated that deoxypodophyllotoxin from Anthriscus sylvestris (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.
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