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Do metastases metastasize?
Catherine R Tait1, D Dodwell, K Horgan
1Department of Surgery, The General Infirmary at Leeds, Great George Street, Leeds, West Yorkshire LS1 3EX, UK. cathytait@doctors.org.uk
The Journal of Pathology
|April 20, 2004
Abstract:
Metastatic disease is a major cause of morbidity and mortality. However, it is not clear if all metastases originate from the primary tumour or whether metastases themselves have the capacity to metastasize. In this review, the evidence for the latter phenomenon, and its biological and clinical implications, is discussed.