[Epidemiology of lip-maxilla-palate clefts in the canton of Vaud]
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Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
Marie-Claude Addor1, Laurence Feldmeyer, Judith Hohlfeld
1Service de Génétique Médicale, CHUV, Lausanne.
Abstract:
Epidemiological variables in oral clefts were examined in a cohort of patients with congenital malformations from the canton of Vaud in Switzerland during the years 1990-1999. Among 77'259 newborns or foetuses, 144 cases of oral clefts were identified in the Registre Vaudois des Anomalies Congénitales (RVAC), yielding a total prevalence of 18.6 per 10'000. These clefts consisted of 84 (58%) cases of cleft lip with or without cleft palate (CL/P) and 60 (42%) cases of cleft palate only (CP). Associated anomalies were found in 45% of cases. Our results are compared with previous reports in other parts of Europe.
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