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Radiosurgery for pituitary metastases.
Yoshiyasu Iwai1, Kazuhiro Yamanaka, Yuji Honda
1Department of Neurosurgery, Osaka City General Hospital, Osaka, Japan. y-iwai@rc5.so-net.ne.jp
Neurologia Medico-Chirurgica
|April 21, 2004
Summary
Gamma knife radiosurgery (GKS) effectively treated pituitary metastases in seven patients. This less invasive approach controlled tumor growth and improved symptoms in most patients, offering a valuable primary treatment option.
Area of Science:
- Neurosurgery
- Radiation Oncology
Background:
- Pituitary metastases are rare and challenging to treat.
- Conventional therapies can be invasive and have significant side effects.
Purpose of the Study:
- To evaluate the efficacy and safety of Gamma Knife radiosurgery (GKS) for pituitary metastases.
- To assess tumor control, clinical symptom improvement, and survival outcomes.
Main Methods:
- Retrospective analysis of seven patients treated with GKS between 1994 and 2003.
- Diagnoses confirmed via MRI and clinical symptoms, or prior surgery.
- Tumor volumes ranged from 0.2 to 9.6 cm³, with marginal doses of 10-14 Gy.
Main Results:
- Tumor growth was controlled in 83% of patients.
- Clinical symptoms improved in 83% of patients.
- Mean survival after GKS was 11.5 months, with five patients dying from systemic disease.
Conclusions:
- Gamma Knife radiosurgery is an effective and less invasive treatment for pituitary metastases.
- GKS demonstrates good tumor control and symptom improvement in patients with limited survival prognosis.