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Related Experiment Videos

Prognostic variables in surgery for skull base meningiomas.

M A Lefkowitz1, D R Hinton, M H Weiss

  • 1Department of Neurosurgery, University of Southern California School of Medicine, Los Angeles, California, USA.

Neurosurgical Focus
|April 15, 1997
PubMed
Summary

Recurrent cranial base meningiomas are linked to muscle and bone invasion. Atypical and anaplastic tumor types are more common in recurrent cases, indicating key features for predicting recurrence.

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Area of Science:

  • Neurosurgery
  • Pathology
  • Oncology

Background:

  • Cranial base meningiomas are tumors that can recur after initial treatment.
  • Identifying predictors of recurrence is crucial for patient management and prognosis.

Purpose of the Study:

  • To retrospectively analyze surgical and pathological factors associated with recurrent cranial base meningiomas.
  • To compare features of recurrent tumors with those of primary meningiomas without recurrence.

Main Methods:

  • Retrospective analysis of 20 patients with recurrent cranial base meningiomas and 34 patients with primary meningiomas.
  • Evaluation of tumor invasion (brain, cranial nerve, carotid artery, muscle, bone), cellularity, nucleolar prominence, pleomorphism, and Ki-67 antigen expression.

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Main Results:

  • Recurrent tumors showed increased cellularity and tumor necrosis more frequently.
  • Atypical and anaplastic meningiomas were significantly more common in the recurrent group (p < 0.02).
  • Invasion of muscle and bone (72%) was more prevalent in recurrent tumors.

Conclusions:

  • Muscle and bone invasion are significant indicators of recurrent skull base meningiomas.
  • Tumor type (atypical, anaplastic) and increased cellularity are associated with tumor recurrence.