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Acute generalized exanthematous pustulosis due to thallium
M H Aziz Jalali1, S Mirzazadeh Javaheri, P Salehian
1Department of Dermatology, Iran University of Medicine, Hazrat Rasoul Hospital, Niyaeh st, Satarkhan Ave, Tehran, Iran. saeidmj@yahoo.com
Summary
Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction. This case highlights radioactive thallium as a potential cause, with symptoms resolving after drug withdrawal and corticosteroid treatment.
Area of Science:
- Dermatology
- Toxicology
- Nuclear Medicine
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse drug reaction.
- It typically presents with fever, pruritus, and widespread pustules.
- Medications are the most common triggers for AGEP.
Observation:
- A patient developed AGEP with characteristic fever and pustular rash.
- The patient had recent exposure to radioactive thallium.
- The eruption appeared following exposure to radioactive thallium.
Findings:
- Radioactive thallium was identified as the causative agent for AGEP in this patient.
- Discontinuation of radioactive thallium led to rapid improvement of the skin eruption.
- Systemic corticosteroid therapy further aided in the resolution of AGEP.
Implications:
- This case expands the known spectrum of drugs causing AGEP.
- It underscores the importance of considering radioactive agents in the differential diagnosis of AGEP.
- Awareness of thallium-induced AGEP can guide prompt diagnosis and management.