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  3. Research Domains
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  3. Research Domains

Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Alcohol Intake And Colorectal Cancer: A Pooled Analysis Of 8 Cohort Studies.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Alcohol Intake And Colorectal Cancer: A Pooled Analysis Of 8 Cohort Studies.

    • Related Experiment Videos

    Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies.

    Eunyoung Cho1, Stephanie A Smith-Warner, John Ritz

    • 1Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Harvard School of Public Health, and Harvard Center for Cancer Prevention, Boston, Massachusetts 02115, USA. eunyoung.cho@channing.harvard.edu

    Annals of Internal Medicine
    |April 21, 2004

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Heavy alcohol consumption is linked to an increased risk of colorectal cancer, particularly at higher intake levels. This association was observed across different parts of the large bowel.

    Related Experiment Videos

    Area of Science:

    • Epidemiology
    • Cancer Research
    • Public Health

    Background:

    • Epidemiologic studies suggest a link between alcohol consumption and colorectal cancer risk.
    • Previous findings on specific beverages and cancer sites have been inconsistent.

    Purpose of the Study:

    • To investigate the association between total alcohol intake and specific beverage consumption with colorectal cancer incidence.
    • To determine if other risk factors modify this relationship.

    Main Methods:

    • Pooled analysis of 8 cohort studies in North America and Europe.
    • Involved 489,979 participants without prior cancer (excluding nonmelanoma skin cancer).
    • Alcohol intake assessed via validated food-frequency questionnaires at baseline.

    Main Results:

    • A total of 4687 colorectal cancer cases were documented over 6-16 years.
    • Increased risk was observed for alcohol intake of 30 grams/day or more.
    • Relative risks were 1.16 (30-45 g/d) and 1.41 (≥45 g/d) compared to nondrinkers.

    Conclusions:

    • A single alcohol intake measurement correlated with a modest increase in colorectal cancer rates.
    • The association was consistent across proximal colon, distal colon, and rectum.
    • Limitations include inability to assess lifetime consumption or changes over time.