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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Endogenous Sex Hormones And Progression Of Carotid Atherosclerosis In Elderly Men.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Endogenous Sex Hormones And Progression Of Carotid Atherosclerosis In Elderly Men.

    • Related Experiment Videos

    Endogenous sex hormones and progression of carotid atherosclerosis in elderly men.

    Majon Muller1, Annewieke W van den Beld, Michiel L Bots

    • 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

    Circulation
    |April 21, 2004

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Low free testosterone levels are linked to atherosclerosis progression in elderly men. This finding highlights the importance of sex hormones in cardiovascular health for aging populations.

    Related Experiment Videos

    Area of Science:

    • Gerontology
    • Cardiovascular Medicine
    • Endocrinology

    Background:

    • Atherosclerosis poses a significant health burden, particularly in the aging population.
    • Emerging research suggests endogenous sex hormones may protect against atherosclerosis in older men.

    Purpose of the Study:

    • To investigate the association between endogenous sex hormones and the progression of atherosclerosis in elderly men.
    • To determine if sex hormone levels predict changes in carotid intima-media thickness over time.

    Main Methods:

    • Longitudinal study of 195 independently living elderly men.
    • Carotid intima-media thickness (IMT) measured at baseline (1996) and follow-up (2000).
    • Serum concentrations of total and free testosterone and total and free estradiol (E2) analyzed at baseline.

    Main Results:

    • Serum free testosterone concentrations showed an inverse relationship with mean IMT progression in the common carotid artery.
    • Higher serum total and free estradiol levels were associated with increased IMT progression in the common carotid artery.
    • These associations remained significant after adjusting for age, BMI, waist-to-hip ratio, hypertension, diabetes, smoking, and cholesterol levels.

    Conclusions:

    • Low levels of free testosterone are independently associated with carotid artery intima-media thickness in elderly men.
    • Sex hormone status, particularly free testosterone, may play a role in the development and progression of atherosclerosis in aging men.