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Related Experiment Videos

Mumps-induced corneal endotheliitis.

Kirti Singh1, Punita Kumari Sodhi

  • 1Department of Ophthalmology, Maulana Azad Medical College and Guru Nanak Eye Center, New Delhi 110002, India. the.singhs@vsnl.com

Cornea
|April 21, 2004
PubMed
Summary
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Corneal endotheliitis, an inflammation of the corneal endothelium, can occur after mumps parotitis. Prompt steroid treatment can fully restore vision in affected patients.

Area of Science:

  • Ophthalmology
  • Virology
  • Immunology

Background:

  • Mumps parotitis is a viral illness typically affecting salivary glands.
  • Ocular complications of mumps are rare, with previous reports focusing on keratitis or uveitis.

Observation:

  • Two patients presented with sudden, unilateral vision loss during the resolution phase of mumps parotitis.
  • Clinical examination revealed central corneal edema without epithelial defects or iridocyclitis.
  • Specular microscopy showed increased corneal thickness and endothelial cell abnormalities.

Findings:

  • Enzyme-linked immunosorbent assay (ELISA) confirmed mumps virus IgM antibodies in patient serum.
  • Routine systemic disease investigations were negative, supporting a diagnosis linked to mumps.

Related Experiment Videos

  • Corneal endotheliitis was identified as a sequela of mumps infection.

    • Implications:

    • This study reports a novel association between mumps parotitis and corneal endotheliitis.
    • Topical corticosteroid therapy resulted in complete visual recovery and resolution of corneal signs.
    • Ophthalmologists should consider mumps as a potential cause of endotheliitis, especially during outbreaks.