Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Highly active antiretroviral therapy improves neurocognitive functioning.

Kevin R Robertson1, Wendy T Robertson, Sutapa Ford

  • 1AIDS Neurological Center Department, Neurology University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7025, USA.

Journal of Acquired Immune Deficiency Syndromes (1999)
|April 21, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preemptive Pediatric Kidney Transplantation and Social Determinants of Health: Individual-Level Versus Area-Based Measures.

Pediatric transplantation·2026
Same author

Beyond biological risk: socioeconomic vulnerability and adverse pediatric kidney transplant outcomes.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Modeling internalizing symptoms in United States veterans using the Hierarchical Taxonomy of Psychopathology (HiTOP) framework: Gender invariance and longitudinal stability.

Journal of psychopathology and clinical science·2026
Same author

Impact of a diagnosis of 'low-grade dysplasia' in patients with Barrett's esophagus.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
Same author

Unraveling Emerging Data on Lipoprotein(a)-Driven Cardiovascular Disease via Multiomics: A Review.

Global heart·2026
Same author

Maternal sFlt-1/PlGF Ratio to Distinguish Pathological Fetal Growth Restriction From Constitutional Smallness: Systematic Review.

BJOG : an international journal of obstetrics and gynaecology·2026

Highly active antiretroviral therapy (HAART) improves HIV systemic health but may poorly affect the nervous system. This study shows HAART significantly improves central nervous system viral load and function in HIV patients short-term.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Pharmacology

Background:

  • Highly active antiretroviral therapy (HAART) significantly improves systemic health in HIV patients.
  • Concerns exist regarding the limited blood-brain barrier penetration of HAART, potentially impacting long-term nervous system function.
  • A progressive decline in neurologic function is a possibility despite adequate systemic HIV response.

Purpose of the Study:

  • To evaluate the short-term effects of HAART on central nervous system (CNS) viral burden and neurological function in HIV-infected individuals.
  • To assess whether HAART improves or exacerbates neurological decline in patients with HIV.
  • To determine the impact of HAART on cerebrospinal fluid (CSF) HIV RNA levels and neuropsychological outcomes.

Main Methods:

Related Experiment Videos

  • Prospective longitudinal study design.
  • Inclusion of 48 subjects initiating HAART.
  • Ultrasensitive HIV RNA quantification in plasma and CSF, alongside neurological and neuropsychological examinations before and 6 months after HAART initiation.

    • Main Results:

    • Significant decline in both plasma and cerebrospinal fluid HIV RNA levels post-HAART.
    • Significant improvement observed in neurological and neuropsychological functioning after 6 months of HAART.
    • Demonstrated satisfactory short-term improvement in CNS viral burden and nervous system function.

    Conclusions:

    • Despite poor CNS penetration, HAART offers significant short-term benefits for HIV patients' nervous system function.
    • HAART effectively reduces viral load within the CNS.
    • Continued longitudinal evaluation is necessary due to the increasing likelihood of treatment failure over time.