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Related Experiment Videos

Clarithromycin-induced eosinophilic pneumonia.

Hiroshi Ohnishi1, Masahiro Abe, Akihito Yokoyama

  • 1Second Department of Internal Medicine, Ehime University School of Medicine, Ehime.

Internal Medicine (Tokyo, Japan)
|April 22, 2004
PubMed
Summary

Clarithromycin (CAM) can cause rare but serious side effects. This case report details an 80-year-old woman who developed eosinophilic pneumonia after starting CAM for a mycobacterial infection.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Infectious Diseases

Background:

  • Clarithromycin (CAM) is a widely used macrolide antibiotic for respiratory infections.
  • Macrolides are generally well-tolerated, with adverse reactions being infrequent.
  • Nontuberculous mycobacterial infections often require combination chemotherapy.

Observation:

  • An 80-year-old female patient with nontuberculous mycobacterial infection was receiving isoniazid, rifampicin, and ethambutol.
  • Three days after initiating clarithromycin (CAM) as add-on therapy, she developed fever and peripheral blood eosinophilia.
  • New subpleural consolidations appeared on chest radiography.

Findings:

  • Symptoms and clinical findings resolved upon discontinuation of clarithromycin (CAM).

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  • Histopathologic examination confirmed the diagnosis of eosinophilic pneumonia.
  • This represents the first documented case of clarithromycin-induced eosinophilic pneumonia.

    • Implications:

    • This case highlights a rare but significant adverse reaction to clarithromycin (CAM).
    • Clinicians should consider eosinophilic pneumonia in patients presenting with compatible symptoms during CAM therapy.
    • Prompt recognition and withdrawal of CAM may lead to favorable outcomes.